Further New Gypenosides from Jiaogulan (Gynostemma pentaphyllum)
Department中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室
Wang J(王君)1,2; Yang JL(杨军丽)1; Zhou, Pan-Pan3; Meng XH(孟宪华)1; Shi YP(师彦平)1; Yang JL(杨军丽)
2017
Source PublicationJournal of Agricultural and Food Chemistry
ISSN0021-8561
Volume65Issue:29Pages:5926-5934
Abstract

Jiaogulan (Gynostemma pentaphyllum) has been widely used as a herbal tea, dietary supplement, and vegetable in Asian countries. In this study, six new gypenosides (16) were isolated from the aerial parts of G. pentaphyllum. Their molecular structures were elucidated through spectroscopic analysis and acid hydrolysis. Gypenosides 1 and 2 represented the first example of a dammar-21-O- glucopyranoside without any unsaturated functional group and a dammar-3-O-glucopyranosyl-25-O-glucopyranoside without any cyclization in the side chain, respectively. In addition, gypenosides 5 and 6 exhibited the first example of a 24-hydroperoxy-19-oxo-dammarane triterpenoid and 19-oxo-dammar-21-O-glucopyranoside with a saturated side chain, respectively. Gypenoside 5 was found to possess protein tyrosine phosphatase 1B inhibitory activity, with an IC50 value of 8.2 ± 0.9 μM, and moderate cytotoxicity against human breast cancer cells MCF7, MCF7/ADR, and MDA-MB-231, with IC50 values ranging from 10.5 ± 1.4 to 14.2 ± 2.6 μM. The outcome of the study provided crucial information regarding the structural diversity and health benefits of gypenosides.

KeywordJiaogulan Gynostemma Pentaphyllum New Gypenosides Ptp1b Inhibitory Activity Cytotoxicity
Subject Area分析化学与药物化学
DOI10.1021/acs.jafc.7b01477
Funding Organizationthe National Natural Science Foundation of China (81673325);the CAS Pioneer Hundred Talents Program;the Top Priority Program of “One-Three-Five” Strategic Planning of the Lanzhou Institute of Chemical Physics of CAS
Indexed BySCI
If3.154
Language英语
Funding Project药物化学成分研究组
compositor第一作者单位
Citation statistics
Cited Times:40[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.licp.cn/handle/362003/22440
Collection中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室
Corresponding AuthorYang JL(杨军丽)
Affiliation1.CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People’s Republic of China
2.University of Chinese Academy of Sciences, Beijing 100039, People’s Republic of China
3.College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, People’s Republic of China
Recommended Citation
GB/T 7714
Wang J,Yang JL,Zhou, Pan-Pan,et al. Further New Gypenosides from Jiaogulan (Gynostemma pentaphyllum)[J]. Journal of Agricultural and Food Chemistry,2017,65(29):5926-5934.
APA Wang J,Yang JL,Zhou, Pan-Pan,Meng XH,Shi YP,&杨军丽.(2017).Further New Gypenosides from Jiaogulan (Gynostemma pentaphyllum).Journal of Agricultural and Food Chemistry,65(29),5926-5934.
MLA Wang J,et al."Further New Gypenosides from Jiaogulan (Gynostemma pentaphyllum)".Journal of Agricultural and Food Chemistry 65.29(2017):5926-5934.
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