Antiviral escin derivatives from the seeds of Aesculus turbinata Blume (Japanese horse chestnut) | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Ji Won Kim1; Thi-Kim-Quy Ha1; Hyomoon Cho1; Eunhee Kim2; Sang Hee Shim3; Yang JL(杨军丽)4; Won Keun Oh1 | |
2017 | |
Source Publication | Bioorganic and Medicinal Chemistry Letters |
ISSN | 0960-894X |
Volume | 27Issue:13Pages:3019-3025 |
Abstract | Porcine epidemic diarrhea virus (PEDV) causes severe diarrhea and high fatality of piglets, influencing the swine industry. Japanese horse chestnut (seed of Aesculus turbinata) contains many saponin mixtures, called escins, and has been used for a long time as a traditional medicinal plant. Structure-activity relationship (SAR) studies on escins have revealed that acylations at C-21 and C-22 with angeloyl or tigloyl groups were important for their cytotoxic effects. However, the strong cytotoxicity of escins makes them hard to utilize for other diseases and to develop as nutraceuticals. In this research, we investigated whether escin derivatives 1-7 (including new compounds 2, 3, 5 and 6), without the angeloyl or tigloyl groups and with modified glycosidic linkages by hydrolysis, have PEDV inhibitory effects with less cytotoxicity. Compounds 1-7 had no cytotoxicity at 20 μM on VERO cells, while compounds 8-10 showed strong cytotoxicity at similar concentrations on PEDV. Our results suggest that escin derivatives showed strong inhibitory activities on PEDV replication with lowered cytotoxicity. These studies propose a method to utilize Japanese horse chestnut for treating PEDV and to increase the diversity of its bioactive compounds. |
Keyword | Porcine Epidemic Diarrhea Virus (Pedv) Horse Chestnut Aesculus Turbinata Escins |
Subject Area | 分析化学与药物化学 |
DOI | 10.1016/j.bmcl.2017.05.022 |
Funding Organization | the Marine Biotechnology Program of the Ministry of Oceans and Fisheries (PJT200669);the Korea Bioactive Natural Material Bank (NRF-2012M3A9B8021570) of the National Research Foundation of Korea (NRF);funded by the Korean government |
Indexed By | SCI |
If | 2.454 |
Language | 英语 |
Funding Project | 药物化学成分研究组 |
compositor | 第四作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/21997 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Won Keun Oh |
Affiliation | 1.Korea Bioactive Natural Material Bank, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea 2.Choong Ang Vaccine Laboratory, 59-3 Hwaam-dong, Yuseong-gu, Daejeon 305-348, Republic of Korea 3.College of Pharmacy, Duksung Women’s University, Seoul, Republic of Korea 4.Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China |
Recommended Citation GB/T 7714 | Ji Won Kim,Thi-Kim-Quy Ha,Hyomoon Cho,et al. Antiviral escin derivatives from the seeds of Aesculus turbinata Blume (Japanese horse chestnut)[J]. Bioorganic and Medicinal Chemistry Letters,2017,27(13):3019-3025. |
APA | Ji Won Kim.,Thi-Kim-Quy Ha.,Hyomoon Cho.,Eunhee Kim.,Sang Hee Shim.,...&Won Keun Oh.(2017).Antiviral escin derivatives from the seeds of Aesculus turbinata Blume (Japanese horse chestnut).Bioorganic and Medicinal Chemistry Letters,27(13),3019-3025. |
MLA | Ji Won Kim,et al."Antiviral escin derivatives from the seeds of Aesculus turbinata Blume (Japanese horse chestnut)".Bioorganic and Medicinal Chemistry Letters 27.13(2017):3019-3025. |
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