Fabrication of large diameter TiO2 nanotube for bone morphogenetic protein-2 delivery | |
Department | 清洁能源化学与材料实验室 |
Liang, Kun1; Li XC(李小成)2; Beng Kang Tay1 | |
2014 | |
Source Publication | International Journal of Nanotechnology |
ISSN | 1475-7435 |
Volume | 11Issue:12Pages:1097-1109 |
Abstract | A localised and release-controlled carrier is essential to enhance the effectiveness of bone morphogenetic protein in bone regeneration and repair. In this work, TiO2 nanotubes with diameter larger than 350 nm were successfully fabricated for the first time by electrochemical method using diethylene glycol electrolyte. The diameter of the nanotubes reaches 550 nm and 680 nm at 90 V and 100 V, respectively. Their influences for bone morphogenetic protein-2 (BMP-2) delivery were investigated. In the study of protein release, fabricated TiO2 nanotubes have shown superhydrophilic properties that induce tight interaction with BMP-2. The release profile of the TiO2 nanotubes demonstrated a larger retention of protein, a more significant suppression of the initial burst and a better retardation of the release rate. Elution profile was also found to be dependent greatly on the density and the diameter of the nanotubes. Results have shown that the initial burst was larger for nanotubes with lower density and more proteins were released from nanotubes with larger diameter for the whole elution process. |
Keyword | Tio2 Nanotube Titanium Dioxide Large Diameter Anodisation Electrochemical Bmp-2 Delivery Protein Elution Nanotechnology |
Subject Area | 材料科学与物理化学 |
DOI | 10.1504/IJNT.2014.065136 |
Indexed By | SCI |
If | 0.618 |
Language | 英语 |
Funding Project | 新型电池材料研究组 |
compositor | 第二作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/21325 |
Collection | 清洁能源化学与材料实验室 |
Corresponding Author | Liang, Kun |
Affiliation | 1.Nanyang Technol Univ, Nanoelect Ctr Excellence, Sch Elect & Elect Engn, NOVITAS, Singapore 639798, Singapore 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Lab Clean Energy Chem & Mat, Lanzhou 730000, Peoples R China |
Recommended Citation GB/T 7714 | Liang, Kun,Li XC,Beng Kang Tay. Fabrication of large diameter TiO2 nanotube for bone morphogenetic protein-2 delivery[J]. International Journal of Nanotechnology,2014,11(12):1097-1109. |
APA | Liang, Kun,Li XC,&Beng Kang Tay.(2014).Fabrication of large diameter TiO2 nanotube for bone morphogenetic protein-2 delivery.International Journal of Nanotechnology,11(12),1097-1109. |
MLA | Liang, Kun,et al."Fabrication of large diameter TiO2 nanotube for bone morphogenetic protein-2 delivery".International Journal of Nanotechnology 11.12(2014):1097-1109. |
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LZ01029785.pdf(1077KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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