Polyphenols Isolated from Xanthoceras sorbifolia Husks and Their Anti-Tumor and Radical-Scavenging Activities | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Yang CY(杨春艳)1,2; Ha W(哈伟)1; Lin, Yong3; Jiang K(姜侃)1; Yang JL(杨军丽)1; Shi YP(师彦平)1; Yang JL(杨军丽); Shi YP(师彦平) | |
2016 | |
Source Publication | Molecules |
ISSN | 1420-3049 |
Volume | 21Issue:12Pages:1964(1-14) |
Abstract | Xanthoceras sorbifolia Bunge. is used in traditional medicine in North China. To evaluate the anti-tumor and radical-scavenging activities of X. sorbifolia husks polyphenols and determine their structure-activity relationships, 37 polyphenols 1–37 were obtained by bioassay-guided fractionation. Two new compounds 1–2, and compounds 5, 6, 8, 9, 11, 14–17, 21–25, 27–29, 31, 33, 34, 36, and 37 were isolated from the genus Xanthoceras for the first time. Compounds 1–37 did not show strong cytotoxicity against the four tested tumor cell lines (A549, HepG2, MGC-803, and MFC) compared to paclitaxel and under the conditions tested in the anti-tumor assay, but compounds 3, 4, 7, 8, 10, 18–20, 25, 26, 29, 30, 32, and 35 exhibited stronger radical-scavenging activity than ascorbic acid in a 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt assay. This was the first report on the anti-tumor and radical-scavenging activities of the polyphenols isolated from X. sorbifolia husks. Overall, the present study contributed valuable information concerning X. sorbifolia husks use in medicine and pharmacology. |
Keyword | Xanthoceras Sorbifolia Polyphenols Extracts Anti-tumor Activity Radical-scavenging Activity |
Subject Area | 分析化学与药物化学 |
DOI | 10.3390/molecules21121694 |
Funding Organization | the National Nature Science Foundation of China (No. 21405164;21575150;81673325);the CAS Pioneer Hundred Talents Program;the scientific research project of Central Asia Drug Discovery and Development Centre of Chinese Academy of Sciences (No. CAM201404);Postdoctoral Research Projects in Gansu Province |
Indexed By | SCI |
If | 2.861 |
Language | 英语 |
Funding Project | 药物化学成分研究组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/21004 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Yang JL(杨军丽); Shi YP(师彦平) |
Affiliation | 1.CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China 2.School of Pharmacy, Institute of Materia Medica, North Sichuan Medical College, Nanchong 637007, China 3.Department of Preventive Medicine, North Sichuan Medical College, Nanchong 637007, China |
Recommended Citation GB/T 7714 | Yang CY,Ha W,Lin, Yong,et al. Polyphenols Isolated from Xanthoceras sorbifolia Husks and Their Anti-Tumor and Radical-Scavenging Activities[J]. Molecules,2016,21(12):1964(1-14). |
APA | Yang CY.,Ha W.,Lin, Yong.,Jiang K.,Yang JL.,...&师彦平.(2016).Polyphenols Isolated from Xanthoceras sorbifolia Husks and Their Anti-Tumor and Radical-Scavenging Activities.Molecules,21(12),1964(1-14). |
MLA | Yang CY,et al."Polyphenols Isolated from Xanthoceras sorbifolia Husks and Their Anti-Tumor and Radical-Scavenging Activities".Molecules 21.12(2016):1964(1-14). |
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