| Induction of Endogenous Reactive Oxygen Species in Mitochondria by Fullerene-Based Photodynamic Therapy | |
| Department | 清洁能源化学与材料实验室 |
Li Q(李倩)1; Liu CG(刘晨光)2; Li HG(李洪光)1 ; Li HG(李洪光)
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| 2016 | |
| Source Publication | Journal of Nanoscience and Nanotechnology
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| ISSN | 1533-4880 |
| Volume | 16Issue:6Pages:5592-5597 |
| Abstract | The production of ROS in mitochondria plays critical role in photodynamic therapy (PDT). The aim of this study was to investigate whether fullerene-based PDT can induce generation of additional endogenous ROS in mitochondria. Chitosan oligosaccharide grafted fullerene conjugate (CS-C-60) was synthesized as a model water-soluble fullerene. The relationship among photodynamic cytotoxicity, intracellular ROS and CS-C-60 amount demonstrated that low dose fullerene could induce generation of endogenous ROS in human malignant melanoma (A375) cells. Laser scanning microscope (LSM) image shows that considerable amount of endogenous ROS was generated in mitochondria even CS-C-60 could not localize into mitochondria. Assay with rotenone shows that PDT-induced endogenous ROS was generated via electron transport chain (ETC). |
| Keyword | Photodynamic Therapy Reactive Oxygen Species Mitochondria Fullerene |
| Subject Area | 材料科学与物理化学 |
| DOI | 10.1166/jnn.2016.11717 |
| Funding Organization | the Hundred Talents Program of Chinese Academy of Sciences (Y20245YBR1);Technology Development Program of Qingdao Government (121413jch) |
| Indexed By | SCI |
| If | 1.483 |
| Language | 英语 |
| Funding Project | 柔性有机太阳能电池研究组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/20893 |
| Collection | 清洁能源化学与材料实验室 |
| Corresponding Author | Li HG(李洪光) |
| Affiliation | 1.Laboratory of Clean Energy Chemistry and Materials, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China 2.College of Marine Life Science, Ocean University of China, Qingdao 266003, China |
| Recommended Citation GB/T 7714 | Li Q,Liu CG,Li HG,et al. Induction of Endogenous Reactive Oxygen Species in Mitochondria by Fullerene-Based Photodynamic Therapy[J]. Journal of Nanoscience and Nanotechnology,2016,16(6):5592-5597. |
| APA | Li Q,Liu CG,Li HG,&李洪光.(2016).Induction of Endogenous Reactive Oxygen Species in Mitochondria by Fullerene-Based Photodynamic Therapy.Journal of Nanoscience and Nanotechnology,16(6),5592-5597. |
| MLA | Li Q,et al."Induction of Endogenous Reactive Oxygen Species in Mitochondria by Fullerene-Based Photodynamic Therapy".Journal of Nanoscience and Nanotechnology 16.6(2016):5592-5597. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 46 Qian Li.pdf（2782KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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