Expedient Synthesis of Substituted Benzoheterocycles using 2-Butoxy-2,3-dihydrofurans as [4+2] Benzannulation Reagents | |
Department | OSSO国家重点实验室 |
Liu, Changhui1; Huang, Wenbo1; Wang, Man1; Pan, Bin1; Gu YL(顾彦龙)1,2; Gu YL(顾彦龙) | |
2016 | |
Source Publication | Advanced Synthesis and Catalysis |
ISSN | 1615-4150 |
Volume | 358Issue:14Pages:2260-2266 |
Abstract | 2-Alkoxy-2,3-dihydrofurans were found to be versatile benzannulation reagents. Indoles can be synthesized in good to excellent yields via the [4+2] annulation of 2-butoxy-2,3-dihydrofuran with pyrroles catalyzed by copper bromide. With the same protocol, carbazoles can also be obtained when indoles are used as starting material with the aid of p-toluenesulfonic acid. This type of benzannulation reagent can also be used to synthesize benzofuran, benzothiophene and naphthalene derivatives in the presence of a catalytic amount of triflic acid in moderate yields. This benzannulation protocol features wide substrate scope and mild reaction condition. Moreover, most of examples have a good regioslectivity. |
Keyword | Benzannulation Benzofurans Carbazoles Copper Dihydrofurans Indoles |
Subject Area | 物理化学与绿色催化 |
DOI | 10.1002/adsc.201600185 |
Funding Organization | National Natural Science Foundation of China (21373093);the Fundamental Research Funds for the Central Universities of China (2014ZZGH019) |
Indexed By | SCI |
If | 5.646 |
Language | 英语 |
compositor | 第二作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/20470 |
Collection | 羰基合成与选择氧化国家重点实验室(OSSO) |
Corresponding Author | Gu YL(顾彦龙) |
Affiliation | 1.Huazhong Univ Sci & Technol, Key Lab Mat Chem Energy Convers & Storage, Hubei Key Lab Mat Chem & Serv Failure, Minist Educ,Sch Chem & Chem Engn, Wuhan 430074, Peoples R China 2.Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China |
Recommended Citation GB/T 7714 | Liu, Changhui,Huang, Wenbo,Wang, Man,et al. Expedient Synthesis of Substituted Benzoheterocycles using 2-Butoxy-2,3-dihydrofurans as [4+2] Benzannulation Reagents[J]. Advanced Synthesis and Catalysis,2016,358(14):2260-2266. |
APA | Liu, Changhui,Huang, Wenbo,Wang, Man,Pan, Bin,Gu YL,&顾彦龙.(2016).Expedient Synthesis of Substituted Benzoheterocycles using 2-Butoxy-2,3-dihydrofurans as [4+2] Benzannulation Reagents.Advanced Synthesis and Catalysis,358(14),2260-2266. |
MLA | Liu, Changhui,et al."Expedient Synthesis of Substituted Benzoheterocycles using 2-Butoxy-2,3-dihydrofurans as [4+2] Benzannulation Reagents".Advanced Synthesis and Catalysis 358.14(2016):2260-2266. |
Files in This Item: | ||||||
File Name/Size | DocType | Version | Access | License | ||
LZ01029333.pdf(1638KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment