| A new isocoumarin from the aerial parts of Aconitum gymnandrum | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Zhao, Jian-Qiang1,3; Wang YM(王衍明)2,3; Wang, Shuo1; Dang, Jun1; Shi YP(师彦平)2 ; Mei, Li-Juan1; Tao, Yan-Duo1
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| 2016 | |
| Source Publication | Natural Product Research
 |
| ISSN | 1478-6419 |
| Volume | 30Issue:15Pages:1746-1752 |
| Abstract | A new isocoumarin, along with 10 known compounds, was isolated from the aerial parts of Aconitum gymnandrum. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Among the known compounds, compound 11 was obtained as a natural product for the first time, which was previously reported as a synthetic product. In addition, compounds 1–5, 7 and 9 were tested for their cytotoxicity against four human cancer cell lines. The results showed that compounds 3, 4 and 7 displayed cytotoxicity against lung cancer A549 and gastric cancer MGC80, respectively, whereas 5 and 9 showed selective cytotoxicity against hepatocellular carcinoma HepG2. |
| Keyword | Aconitum Gymnandrum Isocourmain Cytotoxic Activity |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1080/14786419.2015.1137574 |
| Funding Organization | the Significant Science % Technological Project of Qinghai Province (grant number 2014-GX-A3A) |
| Indexed By | SCI |
| If | 1.828 |
| Language | 英语 |
| Funding Project | 药物化学成分研究组 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/20411 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Mei, Li-Juan; Tao, Yan-Duo |
| Affiliation | 1.Key Laboratory of Tibetan Medicine Research of CAS and Key Laboratory for Tibetan Medicine of Qinghai Province, Northwest Institute of Plateau Biology, Chinese Academy of Science, Xining, P.R. China 2.Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, P.R. China 3.University of Chinese Academy of Sciences, Beijing, P.R. China |
| Recommended Citation GB/T 7714 | Zhao, Jian-Qiang,Wang YM,Wang, Shuo,et al. A new isocoumarin from the aerial parts of Aconitum gymnandrum[J]. Natural Product Research,2016,30(15):1746-1752. |
| APA | Zhao, Jian-Qiang.,Wang YM.,Wang, Shuo.,Dang, Jun.,Shi YP.,...&Tao, Yan-Duo.(2016).A new isocoumarin from the aerial parts of Aconitum gymnandrum.Natural Product Research,30(15),1746-1752. |
| MLA | Zhao, Jian-Qiang,et al."A new isocoumarin from the aerial parts of Aconitum gymnandrum".Natural Product Research 30.15(2016):1746-1752. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| NPR-2016(WangYM,co-a（999KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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