Synthesis of N-substituted phthalimides and their antifungal activity against Alternaria solani and Botrytis cinerea | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Pan L(潘乐)1,2; Li XZ(李秀壮)2; Gong, Chengwen3; Jin H(金辉)2; Qin B(秦波)2; Qin B(秦波) | |
2016 | |
Source Publication | Microbial Pathogenesis |
ISSN | 0882-4010 |
Volume | 95Pages:186-192 |
Abstract | As organosulfur and organophosphorus agents, phaltane and phosmet are facing great challenges for the environmental contamination, mammalian toxicity and increasing resistance with long term use. It is efficient and meaningful to develop phthalimide-based alternatives with non-sulfur and non-phosphorus groups. A series of N-substituted phthalimides were synthesized and their antifungal activity against two disastrous phytopathogenic fungi, Alternaria solani and Botrytis cinerea was evaluated in vitro. Most of them showed significant antifungal activity against both of fungi, or either of them selectively. N-vinylphthalimide (4) and 8-[4-(phthalimide-2-yl) butyloxy] quinoline (13) were identified as the most promising candidates against B. cinerea and A. solani with the IC50 values of 7.92 μg/mL and 10.85 μg/mL respectively. The brief structure-activity relationships have revealed that vinyl, quinolyl, bromide alkyl and benzyl substitutions were appropriate substituents and coupling functional moieties indirectly with optimum alkyl chain was efficient to prepare phthalimides related fungicides. |
Keyword | N-substituted Phthalimides Synthesis Ic50 Values Antifungal Activity |
Subject Area | 分析化学与药物化学 |
DOI | 10.1016/j.micpath.2016.04.012 |
Funding Organization | the National Natural Science Foundation of China (No. 31570354;31070386;21302195;31300290);Agricultural Biotechnology Research and Development Program of Gansu Province (GNSW-2015-25);Cooperation Program to Gansu Province of Lanzhou Branch of the Chinese Academy of Sciences;135 key cultivation program of the Chinese Academy of Sciences;the Province-academy Cooperation Program of Henan Province of China (NO. 102106000021) |
Indexed By | SCI |
If | 2.009 |
Language | 英语 |
Funding Project | 植物化学生态研究组 |
compositor | 第二作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/19966 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Qin B(秦波) |
Affiliation | 1.University of Chinese Academy of Sciences, People's Republic of China 2.Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, People's Republic of China 3.Institute of Chinese Medicinal Herbs, Gansu Academy of Agricultural Sciences, Lanzhou 730070, People's Republic of China |
Recommended Citation GB/T 7714 | Pan L,Li XZ,Gong, Chengwen,et al. Synthesis of N-substituted phthalimides and their antifungal activity against Alternaria solani and Botrytis cinerea[J]. Microbial Pathogenesis,2016,95:186-192. |
APA | Pan L,Li XZ,Gong, Chengwen,Jin H,Qin B,&秦波.(2016).Synthesis of N-substituted phthalimides and their antifungal activity against Alternaria solani and Botrytis cinerea.Microbial Pathogenesis,95,186-192. |
MLA | Pan L,et al."Synthesis of N-substituted phthalimides and their antifungal activity against Alternaria solani and Botrytis cinerea".Microbial Pathogenesis 95(2016):186-192. |
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1-s2.0-S088240101530(822KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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