| A Ruthenium Catalyst with Unprecedented Effectiveness for the Coupling Cyclization of gamma-Amino Alcohols and Secondary Alcohols | |
| Department | OSSO国家重点实验室 |
| Pan, Bing1; Liu, Bo1; Yue, Erlin2; Liu QB(刘庆彬)1; Yang, Xinzheng2; Wang, Zheng1,2; Sun WH(孙文华)2,3; Liu QB(刘庆彬); Sun WH(孙文华) | |
| 2016 | |
| Source Publication | ACS Catalysis
 |
| ISSN | 2155-5435 |
| Volume | 6Issue:2Pages:1247-1253 |
| Abstract | The ruthenium complex (8-(2-diphenylphosphinoethyl)aminotrihydroquinolinyl)(carbonyl)(hydrido)ruthenium chloride exhibited extremely high efficiency toward the coupling cyclization of γ-amino alcohols with secondary alcohols. The corresponding products, pyridine or quinoline derivatives, are obtained in good to high isolated yields. On comparison with literature catalysts whose noble-metal loading with respect to γ-amino alcohols reached 0.5–1.0 mol % for Ru and a record lowest of 0.04 mol % for Ir, the current catalyst achieves the same efficiency with a loading of 0.025 mol % for Ru. The mechanism of acceptorless dehydrogenative condensation (ADC) was proposed on the basis of DFT calculations; in addition, the reactive intermediates were determined by GC-MS, NMR, and single-crystal X-ray diffraction. The catalytic process is potentially suitable for industrial applications. |
| Keyword | Ruthenium Catalyst Coupling Cyclization N-heterocyclic Compound Ad Reaction High Efficiency |
| Subject Area | 物理化学与绿色催化 |
| DOI | 10.1021/acscatal.5b02638 |
| Funding Organization | the National Natural Science Foundation of China (Nos. 21476060;21374123;U1362204;21373228);the Nature Science Foundation of Hebei Province (No. B2014205049), China |
| Indexed By | SCI |
| If | 9.307 |
| Language | 英语 |
| compositor | 第三作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/19732 |
| Collection | 羰基合成与选择氧化国家重点实验室（OSSO） |
| Corresponding Author | Liu QB(刘庆彬); Sun WH(孙文华) |
| Affiliation | 1.Hebei Normal Univ, Coll Chem & Mat Sci, Shijiazhuang 050024, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Pan, Bing,Liu, Bo,Yue, Erlin,et al. A Ruthenium Catalyst with Unprecedented Effectiveness for the Coupling Cyclization of gamma-Amino Alcohols and Secondary Alcohols[J]. ACS Catalysis,2016,6(2):1247-1253. |
| APA | Pan, Bing.,Liu, Bo.,Yue, Erlin.,Liu QB.,Yang, Xinzheng.,...&孙文华.(2016).A Ruthenium Catalyst with Unprecedented Effectiveness for the Coupling Cyclization of gamma-Amino Alcohols and Secondary Alcohols.ACS Catalysis,6(2),1247-1253. |
| MLA | Pan, Bing,et al."A Ruthenium Catalyst with Unprecedented Effectiveness for the Coupling Cyclization of gamma-Amino Alcohols and Secondary Alcohols".ACS Catalysis 6.2(2016):1247-1253. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| acscatal.5b02638.pdf（1220KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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