Solid-phase extraction using bis(indolyl) methane-modified silica reinforced with multiwalled carbon nanotubes for the simultaneous determination of flavonoids and aromatic organic acid preservatives | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Wang N(王娜)1,2,3; Liao Y(廖原)1,2,3; Wang JM(王佳敏)1,2,3; Tang S(汤胜)1,2,3; Shao SJ(邵士俊)1,2; Shao SJ(邵士俊) | |
2015 | |
Source Publication | Journal of Separation Science |
ISSN | 1615-9306 |
Volume | 38Issue:23Pages:4111-4118 |
Abstract | A novel bis(indolyl)methane-modified silica reinforced with multiwalled carbon nanotubes sorbent for solid-phase extraction was designed and synthesized by chemical immobilization of nitro-substituted 3,3′-bis(indolyl)methane on silica modified with multiwalled carbon nanotubes. Coupled with high-performance liquid chromatography analysis, the extraction properties of the sorbent were evaluated for flavonoids and aromatic organic acid compounds. Under optimum conditions, the sorbent can simultaneously extract five flavonoids and two aromatic organic acid preservatives in aqueous solutions in a single-step solid-phase extraction procedure. Wide linear ranges were obtained with correlation coefficients (R2) ranging from 0.9843 to 0.9976, and the limits of detection were in the range of 0.5–5 μg/L for the compounds tested. Compared with the silica modified with multiwalled carbon nanotubes sorbent and the nitro-substituted 3,3′-bis(indolyl)methane-modified silica sorbent, the developed sorbent exhibited higher extraction efficiency toward the selected analytes. The synergistic effect of nitro-substituted 3,3′-bis(indolyl)methane and multiwalled carbon nanotubes not only improved the surface-to-volume ratio but also enhanced multiple intermolecular interactions, such as hydrogen bonds, π–π, and hydrophobic interactions, between the new sorbent and the selected analytes. The as-established solid-phase extraction with high-performance liquid chromatography and diode array detection method was successfully applied to the simultaneous determination of flavonoids and aromatic organic acid preservatives in grape juices with recoveries ranging from 83.9 to 112% for all the selected analytes. |
Keyword | Bis(Indolyl) Methane Flavonoids Multiwalled Carbon Nanotubes Organic Acids Solid-phase Extraction |
Subject Area | 分析化学与药物化学 |
DOI | 10.1002/jssc.201500913 |
Funding Organization | the National Natural Science Foundation of China (20972170;21275150);the Funds for Distinguished Young Scientists of Gansu (1210RJDA013) |
Indexed By | SCI |
If | 2.741 |
Language | 英语 |
Funding Project | 药物分子识别研究组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/19389 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Shao SJ(邵士俊) |
Affiliation | 1.Chinese Acad Sci, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Key Lab Nat Med Gansu Prov, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China |
Recommended Citation GB/T 7714 | Wang N,Liao Y,Wang JM,et al. Solid-phase extraction using bis(indolyl) methane-modified silica reinforced with multiwalled carbon nanotubes for the simultaneous determination of flavonoids and aromatic organic acid preservatives[J]. Journal of Separation Science,2015,38(23):4111-4118. |
APA | Wang N,Liao Y,Wang JM,Tang S,Shao SJ,&邵士俊.(2015).Solid-phase extraction using bis(indolyl) methane-modified silica reinforced with multiwalled carbon nanotubes for the simultaneous determination of flavonoids and aromatic organic acid preservatives.Journal of Separation Science,38(23),4111-4118. |
MLA | Wang N,et al."Solid-phase extraction using bis(indolyl) methane-modified silica reinforced with multiwalled carbon nanotubes for the simultaneous determination of flavonoids and aromatic organic acid preservatives".Journal of Separation Science 38.23(2015):4111-4118. |
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