| Talaromycolides A-C, Novel Phenyl-Substituted Phthalides Isolated from the Green Chinese Onion-Derived Fungus Talaromyces pinophilus AF-02 | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Zhai, Ming-Ming1; Niu, Hai-Tao4; Li, Jie1; Xiao, Hui1; Shi YP(师彦平)2,3 ; Di DL(邸多隆)2,3; Crews, Phillip5; Wu, Quan-Xiang1,2,3
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| 2015 | |
| Source Publication | Journal of Agricultural and Food Chemistry
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| ISSN | 0021-8561 |
| Volume | 63Issue:43Pages:9558-9564 |
| Abstract | The green Chinese onion (Allium fistulosum L.), which is widely cultivated and has been naturalized in many places, is an important spice and vegetable in East and Southeast Asia. It is used to treat the common cold in China. In the ongoing search for antibacterial activity in fungi derived from natural, pungently scented vegetables, the secondary metabolites of Talaromyces pinophilus AF-02, which was isolated from the stem of the green Chinese onion, were investigated. The genus Talaromyces (Trichocomaceae) is an important fungal genus because of its ubiquity and the role of many of its species in food and agriculture production. Three new phthalide derivatives, talaromycolides A–C, 1–3; a new long-chain dicarboxylic acid, 11; and 12 known compounds were isolated from methanolic extracts of this fungus. Their structures were determined via extensive NMR, HR-ESI-MS, and CD spectroscopic analyses. Compounds 1–3 are rare phthalide derivatives with a novel linkage position between the phenyl and phthalide moieties. The biological properties of 1–16 were evaluated using six different bacteria, and 1–3, 5, and 11 exhibited significant antibacterial activity in response to some of the tested strains. |
| Keyword | Talaromyces Pinophilus Ap-02 Green Chinese Onion Allium Fistulosum Talaromycolide Antibacterial Activity |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1021/acs.jafc.5b04296 |
| Funding Organization | the National Natural Science Foundation of China (No. 21202075;21272103);the 111 Project;the Scientific Research Foundation for Returned Overseas Students (No. 45);the Scientific Research Ability Training of Undergraduate Students Majoring in Chemistry by the Two Patters Based on the Tutorial System and Top Students Project (J1103307) |
| Indexed By | SCI |
| If | 2.857 |
| Language | 英语 |
| Funding Project | 药物化学成分研究组;药物工艺标准研究组 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/19075 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Wu, Quan-Xiang |
| Affiliation | 1.Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 4.Ocean Univ Qingdao, Affiliated Hosp, Dept Urol, Qingdao 266003, Peoples R China 5.Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA |
| Recommended Citation GB/T 7714 | Zhai, Ming-Ming,Niu, Hai-Tao,Li, Jie,et al. Talaromycolides A-C, Novel Phenyl-Substituted Phthalides Isolated from the Green Chinese Onion-Derived Fungus Talaromyces pinophilus AF-02[J]. Journal of Agricultural and Food Chemistry,2015,63(43):9558-9564. |
| APA | Zhai, Ming-Ming.,Niu, Hai-Tao.,Li, Jie.,Xiao, Hui.,Shi YP.,...&Wu, Quan-Xiang.(2015).Talaromycolides A-C, Novel Phenyl-Substituted Phthalides Isolated from the Green Chinese Onion-Derived Fungus Talaromyces pinophilus AF-02.Journal of Agricultural and Food Chemistry,63(43),9558-9564. |
| MLA | Zhai, Ming-Ming,et al."Talaromycolides A-C, Novel Phenyl-Substituted Phthalides Isolated from the Green Chinese Onion-Derived Fungus Talaromyces pinophilus AF-02".Journal of Agricultural and Food Chemistry 63.43(2015):9558-9564. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| acs.jafc.5b04296.pdf（493KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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