| Asymmetric total synthesis of (S)-isocorydine | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Zhong, Mei1,2,3; Jiang, Yunbin4; Chen, Yali5; Yan, Qian1,2,3 ; Liu JX(柳军玺)1,2; Di DL(邸多隆)1,2; Liu JX(柳军玺)
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| 2015 | |
| Source Publication | Tetrahedron: Asymmetry
 |
| ISSN | 0957-4166 |
| Volume | 26Issue:20Pages:1145-1149 |
| Abstract | The asymmetric total synthesis of (S)-isocorydine, a potential drug for the cure of hepatocellular carcinoma, is described. Asymmetric transfer hydrogenation of 3,4-dihydroisoquinoline using a chiral Ru(II) catalyst was applied to the synthesis of isocorydine as the key step, in which the ee value achieved is up to 99%. The overall yield is 9.4% after 12 synthetic procedures. |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1016/j.tetasy.2015.09.008 |
| Funding Organization | ‘West Light Program’, of the Chinese Academy of Sciences (090NKCA127);the Science and Technology Program of Gansu (1304FKCA062) |
| Indexed By | SCI |
| If | 2.108 |
| Language | 英语 |
| Funding Project | 药物工艺标准研究组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/19066 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Liu JX(柳军玺) |
| Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China 4.Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China 5.Lanzhou Univ, Sch Basic Med Sci, Gansu Key Lab Preclin Study New Drugs, Inst Pharmacol, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Zhong, Mei,Jiang, Yunbin,Chen, Yali,et al. Asymmetric total synthesis of (S)-isocorydine[J]. Tetrahedron: Asymmetry,2015,26(20):1145-1149. |
| APA | Zhong, Mei.,Jiang, Yunbin.,Chen, Yali.,Yan, Qian.,Liu JX.,...&柳军玺.(2015).Asymmetric total synthesis of (S)-isocorydine.Tetrahedron: Asymmetry,26(20),1145-1149. |
| MLA | Zhong, Mei,et al."Asymmetric total synthesis of (S)-isocorydine".Tetrahedron: Asymmetry 26.20(2015):1145-1149. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 1-s2.0-S095741661500（426KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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