| The Squaramide-Catalyzed 1,3-Dipolar Cycloaddition of Nitroalkenes with N-2,2,2-Trifluoroethylisatin Ketimines: An Approach for the Synthesis of 5 '-Trifluoromethyl-spiro[pyrrolidin-3,2 '-oxindoles] | |
| Department | OSSO国家重点实验室 |
| Sun, Quantao1; Li, Xiaoyuan1; Su, Jinhuan1; Zhao, Long1; Ma, Mingxia1; Zhu, Yuanyuan1; Zhao, Yanyan1; Zhu, Ranran1; Yan, Wenjin1,2; Wang, Kairong1,2; Wang R(王锐)1,2,3; Wang R(王锐) | |
| 2015 | |
| Source Publication | Advanced Synthesis and Catalysis
 |
| ISSN | 1615-4150 |
| Volume | 357Issue:14-15Pages:3187-3196 |
| Abstract | A Cinchona alkaloid-derived squaramide-catalyzed asymmetric cycloaddition of trfluoromethyl-containing azomethine ylides with beta-nitroalkenes was realized under mild conditions. A series of biologically important 5'-trifluoromethyl-spiro[pyrrolidin-3,2'-oxindoles] was synthesized efficiently by this process in excellent yields, enantioseletivities and diastereoselectivities. |
| Keyword | Squaramides 1 3-dipolar Cycloaddition Trifluoromethyl-containing Azomethine Ylides 5 '-trifluoromethyl-spiro-[Pyrrolidin-3 2 '-oxindoles] |
| Subject Area | 物理化学与绿色催化 |
| DOI | 10.1002/adsc.201500416 |
| Funding Organization | the National Natural Science Foundation of China (nos. 21432003;21272108;31200584;91213302);the Key National S&T Program "Major New Drug Development" of the Ministry of Science and Technology of China (2012ZX09504001-003) |
| Indexed By | SCI |
| If | 6.453 |
| Language | 英语 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/19058 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Yan, Wenjin; Wang, Kairong; Wang R(王锐) |
| Affiliation | 1.Lanzhou Univ, Sch Basic Med Sci, Inst Pharmacol, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China 3.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China |
| Recommended Citation GB/T 7714 | Sun, Quantao,Li, Xiaoyuan,Su, Jinhuan,et al. The Squaramide-Catalyzed 1,3-Dipolar Cycloaddition of Nitroalkenes with N-2,2,2-Trifluoroethylisatin Ketimines: An Approach for the Synthesis of 5 '-Trifluoromethyl-spiro[pyrrolidin-3,2 '-oxindoles][J]. Advanced Synthesis and Catalysis,2015,357(14-15):3187-3196. |
| APA | Sun, Quantao.,Li, Xiaoyuan.,Su, Jinhuan.,Zhao, Long.,Ma, Mingxia.,...&王锐.(2015).The Squaramide-Catalyzed 1,3-Dipolar Cycloaddition of Nitroalkenes with N-2,2,2-Trifluoroethylisatin Ketimines: An Approach for the Synthesis of 5 '-Trifluoromethyl-spiro[pyrrolidin-3,2 '-oxindoles].Advanced Synthesis and Catalysis,357(14-15),3187-3196. |
| MLA | Sun, Quantao,et al."The Squaramide-Catalyzed 1,3-Dipolar Cycloaddition of Nitroalkenes with N-2,2,2-Trifluoroethylisatin Ketimines: An Approach for the Synthesis of 5 '-Trifluoromethyl-spiro[pyrrolidin-3,2 '-oxindoles]".Advanced Synthesis and Catalysis 357.14-15(2015):3187-3196. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| LZ01028475.pdf（832KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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