Condition-Determined Multicomponent Reactions of 1,3-Dicarbonyl Compounds and Formaldehyde | |
Department | OSSO国家重点实验室 |
Liu, Changhui1; Shen, Meng1; Lai, Bingbing1; Taheri, Amir1; Gu YL(顾彦龙)1,2; Gu YL(顾彦龙) | |
2014 | |
Source Publication | ACS Combinatorial Science |
ISSN | 2156-8952 |
Volume | 16Issue:11Pages:652-660 |
Abstract | By means of changing the reaction parameters, different products could be generated selectively starting from the same combination of substrates involving 1,3-dicarbonyl compounds and formaldehyde. This strategy enabled us to access diverse molecules without changing both starting material and reactor, maximizing thus the multifunctionality of the synthetic system. For example, starting from a 1,3-dicarbonyl compound, formaldehyde and 1,1-diphenylethylene, two kinds of products could be selectively formed including (i) a densely substituted dihydropyran and (ii) a C2-cinnamyl substituted 1,3-dicarbonyl compound. A one-pot three-component reaction of phenacylpyridinium salt, 1,3-dicarbonyl compound, and formaldehyde was also investigated, which produced either 2,4-diacyl-2,3-dihydrofuran or 2,4-diacyl-2-hydroxylmethyl-2,3-dihydrofuran in good to excellent yield. |
Keyword | Multicomponent Reactions Diversity-oriented Synthesis Condition-determined Mcr Combinatorial Chemistry |
Subject Area | 物理化学与绿色催化 |
DOI | 10.1021/c05001019 |
Funding Organization | National Natural Science Foundation of China (Grants 21173089;21373093);the Analytical and Testing Center of HUST. Chutian Scholar Program of the Hubei Provincial Government and the Cooperative Innovation Center of Hubei Province;the Fundamental Research Funds for the Central Universities of China (Grant 2014ZZGH019) |
Indexed By | SCI |
If | 3.032 |
Language | 英语 |
compositor | 第二作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/18794 |
Collection | 羰基合成与选择氧化国家重点实验室(OSSO) |
Corresponding Author | Gu YL(顾彦龙) |
Affiliation | 1.Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Large Format Battery Mat & Syst, Minist Educ, Wuhan 430074, Peoples R China 2.Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China |
Recommended Citation GB/T 7714 | Liu, Changhui,Shen, Meng,Lai, Bingbing,et al. Condition-Determined Multicomponent Reactions of 1,3-Dicarbonyl Compounds and Formaldehyde[J]. ACS Combinatorial Science,2014,16(11):652-660. |
APA | Liu, Changhui,Shen, Meng,Lai, Bingbing,Taheri, Amir,Gu YL,&顾彦龙.(2014).Condition-Determined Multicomponent Reactions of 1,3-Dicarbonyl Compounds and Formaldehyde.ACS Combinatorial Science,16(11),652-660. |
MLA | Liu, Changhui,et al."Condition-Determined Multicomponent Reactions of 1,3-Dicarbonyl Compounds and Formaldehyde".ACS Combinatorial Science 16.11(2014):652-660. |
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co5001019.pdf(1049KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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