| An NBD-based Fluorescent Probe with High Selectivity to Cysteine over Homocysteine under Neutral Physiological Conditions | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Wang JM(王佳敏)1,2,3 ; Liao Y(廖原)1,2,3; Shao SJ(邵士俊)1,2
| |
| 2015 | |
| Source Publication | Chemistry Letters
 |
| ISSN | 0366-7022 |
| Volume | 44Issue:10Pages:1437-1439 |
| Abstract | 7-nitro-2,1,3-benzoxadiazole (NBD)-based fluorescent probe for the detection of cysteine (Cys) over homocysteine (Hcy) and amino acids under neutral physiological conditions based on thiol-induced aromatic nucleophilic substitution reaction was synthesized by the reaction of 4-chloro-7-nitro-2,1,3-benzoxadiazole (NBD-Cl) with p-thiocresol. The proposed sensing mechanism was proved by mass spectrometry of the reaction mixtures. This probe was successfully applied to the fluorescence imaging of Cys in HeLa cells. |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1246/cl.150544 |
| Indexed By | SCI |
| If | 1.550 |
| Language | 英语 |
| Funding Project | 药物分子识别研究组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/18722 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Wang JM,Liao Y,Shao SJ. An NBD-based Fluorescent Probe with High Selectivity to Cysteine over Homocysteine under Neutral Physiological Conditions[J]. Chemistry Letters,2015,44(10):1437-1439. |
| APA | Wang JM,Liao Y,&Shao SJ.(2015).An NBD-based Fluorescent Probe with High Selectivity to Cysteine over Homocysteine under Neutral Physiological Conditions.Chemistry Letters,44(10),1437-1439. |
| MLA | Wang JM,et al."An NBD-based Fluorescent Probe with High Selectivity to Cysteine over Homocysteine under Neutral Physiological Conditions".Chemistry Letters 44.10(2015):1437-1439. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| s1-ln208275691402264（626KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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