Copper-Catalyzed alpha-Benzylation of Enones via Radical-Triggered Oxidative Coupling of Two C-H Bonds

doi:10.1021/acscatal.5b00310

	Copper-Catalyzed alpha-Benzylation of Enones via Radical-Triggered Oxidative Coupling of Two C-H Bonds
Department	OSSO国家重点实验室
	Qin GP(秦贵平); Chen XN(陈向宁); Yang L(杨磊); Huang HM(黄汉民); Huang HM(黄汉民)
	2015
Source Publication	ACS Catalysis
ISSN	2155-5435
Volume	5 Issue:5 Pages:2882-2885
Abstract	A novel copper(II)-catalyzed, regioselective C–H benzylation of enones with toluenes via radical triggered oxidative coupling has been developed. A series of enones and toluenes with different substituents were successfully incorporated, providing a wide range of α-benzylated enones with TBP as oxidant by cleavage of C(sp³)–H bond and C(sp²)–H bond. Preliminary mechanistic study reveals a benzylic carbon radical is generated, and regioselectively reacts with enones to deliver the corresponding products.
Keyword	Oxidative Coupling C-h Activation Radical Copper Catalysis Benzylation Enones Regioselectivity
Subject Area	物理化学与绿色催化
DOI	10.1021/acscatal.5b00310
Funding Organization	the Chinese Academy of Sciences;the National Natural Science Foundation of China (21222203;21372231;21133011)
Indexed By	SCI
If	9.307
Language	英语
Funding Project	有机功能材料研究组
compositor	第一作者单位
Citation statistics	Cited Times:66[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.licp.cn/handle/362003/18439
Collection	羰基合成与选择氧化国家重点实验室（OSSO）
Corresponding Author	Huang HM(黄汉民)
Affiliation	Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China
Recommended Citation GB/T 7714	Qin GP,Chen XN,Yang L,et al. Copper-Catalyzed alpha-Benzylation of Enones via Radical-Triggered Oxidative Coupling of Two C-H Bonds[J]. ACS Catalysis,2015,5(5):2882-2885.
APA	Qin GP,Chen XN,Yang L,Huang HM,&黄汉民.(2015).Copper-Catalyzed alpha-Benzylation of Enones via Radical-Triggered Oxidative Coupling of Two C-H Bonds.ACS Catalysis,5(5),2882-2885.
MLA	Qin GP,et al."Copper-Catalyzed alpha-Benzylation of Enones via Radical-Triggered Oxidative Coupling of Two C-H Bonds".ACS Catalysis 5.5(2015):2882-2885.

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