| Regioselective Direct C-3 Arylation of Imidazo[1,2-a]pyridines with Aryl Tosylates and Mesylates Promoted by Palladium-Phosphine Complexes | |
| Department | OSSO国家重点实验室 |
Choy, Pui Ying1; Luk, Kwan Chak1; Wu, Yinuo1,2; So, Chau Ming1; Wang LL(王来来)3 ; Kwong, Fuk Yee1; Wang LL(王来来)
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| 2015 | |
| Source Publication | Journal of Organic Chemistry
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| ISSN | 0022-3263 |
| Volume | 80Issue:3Pages:1457-1463 |
| Abstract | Direct C-3 arylation of imidazo[1,2-a]pyridines with aryl tosylates and mesylates has been accomplished by employing palladium(II) acetate associated with SPhos (2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl) or L1 (2-(2-(diisopropylphosphino)phenyl)-1-methyl-1H-indole). This catalyst system can be applied to a wide range of aryl sulfonates and shows excellent C-3 regioselectivity of imidazo[1,2-a]pyridine. These results represent the first examples of using tosylate- and mesylate-functionalized arenes as the electrophile partners for this regioselective direct arylation. |
| Subject Area | 物理化学与绿色催化 |
| DOI | 10.1021/jo502386w |
| Funding Organization | the Research Grants Council of Hong Kong (GRF: PolyU5010/13P);State Key Laboratory of Chirosciences;the Croucher Foundation for the Croucher Senior Research Fellowship (2013) |
| Indexed By | SCI |
| If | 4.785 |
| Language | 英语 |
| Funding Project | 有机功能材料研究组 |
| compositor | 第三作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/18361 |
| Collection | 羰基合成与选择氧化国家重点实验室（OSSO） |
| Corresponding Author | Kwong, Fuk Yee; Wang LL(王来来) |
| Affiliation | 1.State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 2.School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China 3.State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China |
| Recommended Citation GB/T 7714 | Choy, Pui Ying,Luk, Kwan Chak,Wu, Yinuo,et al. Regioselective Direct C-3 Arylation of Imidazo[1,2-a]pyridines with Aryl Tosylates and Mesylates Promoted by Palladium-Phosphine Complexes[J]. Journal of Organic Chemistry,2015,80(3):1457-1463. |
| APA | Choy, Pui Ying.,Luk, Kwan Chak.,Wu, Yinuo.,So, Chau Ming.,Wang LL.,...&王来来.(2015).Regioselective Direct C-3 Arylation of Imidazo[1,2-a]pyridines with Aryl Tosylates and Mesylates Promoted by Palladium-Phosphine Complexes.Journal of Organic Chemistry,80(3),1457-1463. |
| MLA | Choy, Pui Ying,et al."Regioselective Direct C-3 Arylation of Imidazo[1,2-a]pyridines with Aryl Tosylates and Mesylates Promoted by Palladium-Phosphine Complexes".Journal of Organic Chemistry 80.3(2015):1457-1463. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| jo502386w.pdf（728KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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