Biocompatible Magnetic and Molecular Dual-Targeting Polyelectrolyte Hybrid Hollow Microspheres for Controlled Drug Release | |
Department | 环境材料与生态化学研究发展中心 |
Du, Pengcheng1,2; Zeng, Jin1,2; Mu B(牟斌)3; Liu P(刘鹏)1,2 | |
2013 | |
Source Publication | Molecular Pharmaceutics |
ISSN | 1543-8384 |
Volume | 10Issue:5Pages:1705-1715 |
Abstract | Well-defined biocompatible magnetic and molecular dual-targeting polyelectrolyte hybrid hollow microspheres have been accomplished via the layer-by-layer (LbL) self-assembly technique. The hybrid shell was fabricated by the electrostatic interaction between the polyelectrolyte cation, chitosan (CS), and the hybrid anion, citrate modified ferroferric oxide nanoparticles (Fe3O4-CA), onto the uniform polystyrene sulfonate microsphere templates. Then the magnetic hybrid core/shell composite particles were modified with a linear, functional poly(ethylene glycol) (PEG) monoterminated with a biotargeting molecule (folic acid (FA)). Afterward the dual targeting hybrid hollow microspheres were obtained after etching the templates by dialysis. The dual targeting hybrid hollow microspheres exhibit exciting pH response and stability in high salt-concentration media. Their pH-dependent controlled release of the drug molecule (anticancer drug, doxorubicin (DOX)) was also investigated in different human body fluids. As expected, the cell viability of the HepG2 cells which decreased more rapidly was treated by the FA modified hybrid hollow microspheres rather than the unmodified one in the in vitro study. The dual-targeting hybrid hollow microspheres demonstrate selective killing of the tumor cells. The precise magnetic and molecular targeting properties and pH-dependent controlled release offers promise for cancer treatment. |
Keyword | Biocompatible Polyelectrolyte Hybrid Hollow Microspheres Magnetic And Molecular Dual-targeting Ph And Ionic Strength Dual-responsive Layer-by-layer Assembly Aggregation-resistant |
Subject Area | 环境材料与生态化学 |
DOI | 10.1021/mp300534a |
Funding Organization | the National Nature Science Foundation of China (Grant No. 20904017) ; the Program for New Century Excellent Talents in University (Grant No. NCET-09-0441) ; the Fundamental Research Funds for the Central Universities (Grant No. lzujbky-2012-k12) |
Indexed By | SCI |
If | 4.787 |
Language | 英语 |
Funding Project | 功能复合材料组 |
compositor | 第三作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/18249 |
Collection | 环境材料与生态化学研究发展中心 |
Corresponding Author | Liu P(刘鹏) |
Affiliation | 1.Lanzhou Univ, State Key Lab Appl Organ Chem, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China 2.Lanzhou Univ, Inst Polymer Sci & Engn, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Lanzhou Inst Chem Phys, Ctr Ecomat & Green Chem, Lanzhou 730000, Peoples R China |
Recommended Citation GB/T 7714 | Du, Pengcheng,Zeng, Jin,Mu B,et al. Biocompatible Magnetic and Molecular Dual-Targeting Polyelectrolyte Hybrid Hollow Microspheres for Controlled Drug Release[J]. Molecular Pharmaceutics,2013,10(5):1705-1715. |
APA | Du, Pengcheng,Zeng, Jin,Mu B,&Liu P.(2013).Biocompatible Magnetic and Molecular Dual-Targeting Polyelectrolyte Hybrid Hollow Microspheres for Controlled Drug Release.Molecular Pharmaceutics,10(5),1705-1715. |
MLA | Du, Pengcheng,et al."Biocompatible Magnetic and Molecular Dual-Targeting Polyelectrolyte Hybrid Hollow Microspheres for Controlled Drug Release".Molecular Pharmaceutics 10.5(2013):1705-1715. |
Files in This Item: | ||||||
File Name/Size | DocType | Version | Access | License | ||
LZ01027733.pdf(612KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment