| Core-shell nanocarriers with ZnO quantum dots-conjugated Au nanoparticle for tumor-targeted drug delivery | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Chen, Tong1; Zhao, Tong1; Wei, Dongfeng3; Wei, Yanxia3; Li, Yuanyuan1; Zhang, Haixia1,2 | |
| 2013 | |
| Source Publication | Carbohydrate Polymers
 |
| ISSN | 0144-8617 |
| Volume | 92Issue:2Pages:1124-1132 |
| Abstract | Core-shell structured multifunctional nanocarriers (NCs) of ZnO quantum dots-conjugated gold nanoparticles (Au NPs) as core and amphiphilic hyperbranched block copolymer as shell were synthesized for targeted anticancer drug delivery. The amphiphilic hyperbranched block copolymer contained poly(L-lactide) (PLA) inner arm and folate (FA)-conjugated a sulfated polysaccharide from Gynostemma pentaphyllum Makino (GPPS-FA) outer arm. The structure and properties of core-shell structured multifunctional nanocarriers were characterized and determined by UV-visible spectra, FT-IR spectra, X-ray diffraction (XRD), fluorescence spectroscopy and TEM analyses. The release results indicated that camptothecin (CPT) release from NCs at pH 7.4 was much greater than that at pH 5.3. The cytotoxicity studies showed that both the blank NCs and the CPT-loaded NCs provided high anticancer activity against Hela cells. Furthermore, nanocarriers gained specificity to target model cancer cells in this study due to the enhanced cell uptake mediated by FA moiety. The results indicated that the NCs not only had great potential as tumor-targeted drug delivery nanocarrier, but also had an assistant role in the treatment of cancer. |
| Keyword | Nanocarriers Drug Delivery Zno Quantum Dots Cytotoxicity |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1016/j.carbpol.2012.10.022 |
| Funding Organization | the Fundamental Research Funds for Central Universities (no. lzujbky-2012-k09); the National Natural Science Foundation of China (no. 21105039) |
| Indexed By | SCI |
| If | 3.916 |
| Language | 英语 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/18230 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Zhang, Haixia |
| Affiliation | 1.Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China 3.Lanzhou Univ, Sch Basic Med Sci, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Chen, Tong,Zhao, Tong,Wei, Dongfeng,et al. Core-shell nanocarriers with ZnO quantum dots-conjugated Au nanoparticle for tumor-targeted drug delivery[J]. Carbohydrate Polymers,2013,92(2):1124-1132. |
| APA | Chen, Tong,Zhao, Tong,Wei, Dongfeng,Wei, Yanxia,Li, Yuanyuan,&Zhang, Haixia.(2013).Core-shell nanocarriers with ZnO quantum dots-conjugated Au nanoparticle for tumor-targeted drug delivery.Carbohydrate Polymers,92(2),1124-1132. |
| MLA | Chen, Tong,et al."Core-shell nanocarriers with ZnO quantum dots-conjugated Au nanoparticle for tumor-targeted drug delivery".Carbohydrate Polymers 92.2(2013):1124-1132. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Carbohydrate Polymer（1481KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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