| Anti-oxidative action of ent-kaurene diterpenoids | |
| Department | 甘肃省天然药物重点实验室 |
| Liu GA(刘国安); Ding L(丁兰); Yang Y(杨艳); Yang H(杨红); Yang QM(杨庆明); Wang HQ(汪汉卿) | |
| 2006 | |
| Source Publication | Res. Chem. Intermed
 |
| ISSN | 0922-6168 |
| Volume | 32Issue:8Pages:787-794 |
| Abstract | Nine ent-kaurene diterpenoids, leukamenin E, glaucocalyxin A, wangzaozi A, epinodisinol, epinodosin, rabdosin B, rabdosinate, lasiokaurin and oridonin, were separated from Isodon racemosa (Hemsl) Hara and Isodon japonica (Burm.f) Hara var. galaucocalyx (maxin). The protection against DNA damage induced by hydrogen peroxide in human peripheral blood mononuclear cells (PBMCs) and inhibition of lipid peroxidation in rat liver microsome were studied with comet assay and thiobarbituric acid reactive substances determination. All nine diterpenoids showed concentration-dependent protection in DNA damage in human PBMCs induced by 50 μMH2O2.The effects were similar and weaker than quercetin. The inhibitions of lipid peroxidation were obviously difference. Rabdosin B and oridonin were the strongest inhibitors, followed by lasiokaurin and wangzaozin A. Rabdosinate was the weakest and others were medium. The structure–activity relationship is discussed. |
| Keyword | Dna Damage Protection Ent-kaurene Diterpenoids Inhibition Lipid Peroxidation Comet Assay |
| Subject Area | 分析化学与药物化学 |
| Funding Organization | NWNUKJCXGC-02;National Natural Science Foundation of China (No-20274034) |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 药物化学成分研究组 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/1495 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Wang HQ(汪汉卿) |
| Recommended Citation GB/T 7714 | Liu GA,Ding L,Yang Y,et al. Anti-oxidative action of ent-kaurene diterpenoids[J]. Res. Chem. Intermed,2006,32(8):787-794. |
| APA | 刘国安,丁兰,杨艳,杨红,杨庆明,&汪汉卿.(2006).Anti-oxidative action of ent-kaurene diterpenoids.Res. Chem. Intermed,32(8),787-794. |
| MLA | 刘国安,et al."Anti-oxidative action of ent-kaurene diterpenoids".Res. Chem. Intermed 32.8(2006):787-794. |
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