Ultrasensitive electrochemical sensing of the anticancer drug tirapazamine using an ordered mesoporous carbon modified pyrolytic graphite electrode | |
Department | 甘肃省天然药物重点实验室 |
Hu GZ(胡广志); Guo Y(郭勇); Shao SJ(邵士俊) | |
2009 | |
Source Publication | Biosensors and Bioelectronics |
ISSN | 0956-5663 |
Volume | 24Pages:3391-3394 |
Abstract | A new ordered mesoporous carbon (OMC) modified pyrolytic graphite electrode (PGE) was prepared to investigate electrochemical behavior of the anticancer drug tirapazamine (TPZ). Compared to the bare PGE, themodifiedelectrode showedanexcellent electrochemical response to TPZ. The anodic peak current (Ipa) of TPZ at the OMC/PGE is 180-fold higher than that of the bare PGE. The Ipa is proportional with TPZ concentration in the range of 5.0×10−11 to 1.5×10−5 mol L−1. The linear regression equations are Ipa ( A) = 0.0000044 + 16.928CTPZ ( mol L−1), with a detection limit (S/N = 3) of 2.0×10−11 mol L−1. This proposedmethod can be potentially used for ultrasensitive electrochemical sensing of TPZ inphysiological condition. |
Keyword | Ordered Mesoporous Carbon Tirapazamine Electrochemical Sensor Ultrasensitive Determination |
Subject Area | 分析化学与药物化学 |
Funding Organization | National Nature Science Foundation of China (No. 20672121) |
Indexed By | SCI |
Language | 英语 |
Funding Project | 药物分子识别研究组 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/1186 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Shao SJ(邵士俊) |
Recommended Citation GB/T 7714 | Hu GZ,Guo Y,Shao SJ. Ultrasensitive electrochemical sensing of the anticancer drug tirapazamine using an ordered mesoporous carbon modified pyrolytic graphite electrode[J]. Biosensors and Bioelectronics,2009,24:3391-3394. |
APA | 胡广志,郭勇,&邵士俊.(2009).Ultrasensitive electrochemical sensing of the anticancer drug tirapazamine using an ordered mesoporous carbon modified pyrolytic graphite electrode.Biosensors and Bioelectronics,24,3391-3394. |
MLA | 胡广志,et al."Ultrasensitive electrochemical sensing of the anticancer drug tirapazamine using an ordered mesoporous carbon modified pyrolytic graphite electrode".Biosensors and Bioelectronics 24(2009):3391-3394. |
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